Cost reduction is one of the five major tasks of the supply-side structural reform of “three to one, one to reduce and one to supplement”. In recent years, Zhengzhou municipal party Committee and municipal government, in accordance with the arrangements of the party central Committee and the state Council, have further promoted various work to reduce the costs of real economic enterprises and achieved outstanding results. In order to further grasp the operation of Zhengzhou’s real economic enterprises and push forward Zhengzhou’s cost reduction work in depth, based on a careful study of the large-scale “cost reduction” survey conducted by the China Institute of Financial Sciences in 2017-2019 and the survey conducted by the Institute of Geography and Resources of the Chinese Academy of Sciences on Zhengzhou’s business environment evaluation, this paper conducts a special survey in all development zones, county (city) districts and relevant municipal departments of the city, conscientiously summarizes and analyzes Zhengzhou’s cost reduction policies and measures, achievements and difficult challenges, and puts forward relevant countermeasures and suggestions for further cost reduction.